Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266
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منابع مشابه
Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266.
It has been reported recently that freshly isolated human myeloma cell cultures proliferate in response to added interleukin-6 (IL-6). Endogenous levels of IL-6 found in the same cultures suggested that an autocrine growth loop may contribute to cell growth. However, the lack of homogenous cell populations in primary myeloma cultures has made it difficult to distinguish between paracrine and au...
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Newer therapeutic strategies for the treatment of multiple myeloma have focused on antagonizing the growth-promoting functions of interleukin 6 (IL-6). In this study, we examined the antitumor effects of two mechanistically different microtubule poisons, Taxol and vinblastine, in U266 human myeloma cells and determined whether IL-6 altered these effects. Taxol and vinblastine led to a dose-depe...
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Accessible online at: www.karger.com/onk Fax +49 761 4 52 07 14 E-mail [email protected] www.karger.com tract, both on the protein level and on the mRNA level (as shown by real time-RT-PCR). What can we learn from these studies? – Very little. First, it is not particularly surprising to see that lymphoid tumor cells do not respond when stimulated with a multi-component plant extract. Second...
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ژورنال
عنوان ژورنال: Blood
سال: 1991
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v77.3.587.587